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Toxin Induction and Protein Extraction from Fusarium spp. Cultures for Proteomic Studies
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Total synthesis of the Fusarium toxin equisetin

Lisa T Burke1, Darren J Dixon, Steven V Ley

  • 1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.

Organic & Biomolecular Chemistry
|January 6, 2005
PubMed

Abstract:

A short stereoselective synthesis of the Fusarium toxin equisetin, a potent inhibitor of HIV-1 integrase enzyme is described, using as the key step a stereoselective intramolecular Diels-Alder reaction of a fully conjugated E,E,E-triene with a trisubstituted gamma,delta-unsaturated beta-ketothioester.

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