Related Experiment Video

Updated: Aug 7, 2026

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis
07:15

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis

Published on: October 21, 2013

Imaging of macrophage-related lung diseases

Katharina Marten1, David M Hansell

  • 1Department of Radiology, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK.

European Radiology
|January 6, 2005
PubMed

Insights

Macrophage-related lung diseases involve abnormal macrophage activity, leading to conditions like interstitial lung diseases and tumors. Imaging reveals characteristic patterns such as ground-glass opacities and nodules due to macrophage accumulation and dysfunction.

Area of Science:

  • Pulmonary Medicine
  • Pathology
  • Radiology

Background:

  • Macrophage-related pulmonary diseases encompass a diverse range of lung disorders.
  • These conditions are defined by aberrant macrophage accumulation, activation, or impaired function.
  • Examples include smoking-related interstitial lung diseases, metabolic storage disorders, and primary lung tumors.

Purpose of the Study:

  • To elucidate the spectrum of macrophage-related pulmonary diseases.
  • To correlate clinical conditions with specific high-resolution computed tomography (HRCT) findings.
  • To understand the role of macrophages in lung pathology and matrix remodeling.

Main Methods:

  • Review of clinical cases and imaging findings in patients with macrophage-related lung diseases.
  • Correlation of HRCT features with underlying macrophage pathobiology.
  • Pathological examination of lung tissue to confirm macrophage involvement.

Main Results:

  • HRCT findings associated with macrophage infiltration include ground-glass opacification.
  • Centrilobular nodules and interlobular septal thickening indicate peribronchiolar and septal macrophage accumulation.
  • Macrophage dysfunction contributes to emphysema, and matrix remodeling leads to honeycombing.

Conclusions:

  • Macrophage dysregulation is a central mechanism in various pulmonary diseases.
  • HRCT imaging provides valuable insights into the presence and distribution of macrophages in the lungs.
  • Understanding these macrophage-driven processes is crucial for diagnosis and management of these lung conditions.

More Related Videos

Visualizing Macrophage Extracellular Traps Using Confocal Microscopy09:14

Visualizing Macrophage Extracellular Traps Using Confocal Microscopy

Published on: October 19, 2017

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment07:21

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Published on: June 23, 2019

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...