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Hyponatremic coma under oxcarbazepine therapy
B J Steinhoff1, K D Stoll, S R Stodieck
1Neurologische Klinik, Ludwig-Maximilians-Universität München, Germany.
Epilepsy Research
|March 1, 1992
Abstract:
Oxcarbazepine (OXC) is considered to be a promising new antiepileptic drug with similar efficacy and better tolerability compared to carbamazepine (CBZ). However, hyponatremia is supposed to occur even more often than with CBZ. We report on a patient who developed hyponatremic coma under OXC with a serum sodium level of 115 mmol/l, the second published case of OXC-induced hyponatremia with serious clinical adverse effects.