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Role of programmed cell death in normal neuronal development and function.

Robert R Buss1, Ronald W Oppenheim

  • 1Department of Neurobiology and Anatomy and the Neuroscience Program, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1010, USA.

Anatomical Science International
|January 7, 2005
PubMed
Summary
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Eliminating programmed cell death in developing nervous systems can cause malformations or excess neurons. Some "undead" neurons function, while others fail to connect, impacting brain structure.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Programmed cell death (PCD) is crucial for nervous system development.
  • Understanding PCD's role in neural development is essential for developmental neuroscience.

Purpose of the Study:

  • To examine the consequences of eliminating programmed cell death during nervous system development.
  • To review studies in model organisms where PCD genes are mutated.

Main Methods:

  • Review of studies in Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, and Mus musculus.
  • Analysis of genetic mutations affecting programmed cell death in the nervous system.

Main Results:

  • Eliminating PCD can lead to embryonic mortality or anatomical malformations.

Related Experiment Videos

  • Some animals develop with excess neurons and glia, with "undead" cells differentiating or failing to connect.
  • Gross brain structure sculpting during neural tube development appears dependent on PCD.

    • Conclusions:

    • Programmed cell death plays a significant role in shaping the developing nervous system.
    • The impact of preventing neuronal cell death later in development is still under investigation.