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Updated: Aug 13, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Spontaneously developing autoantibody to factor VIII in an elderly woman: diagnostic and therapeutic challenges
A D Gupta1, M Mandolkar, Monisha Sethi
1Department of Medicine, PDHinduia National Hospital and Medical Research Centre (National Health and Education Society), Mumbai.
Abstract:
An elderly woman with a continuously bleeding small wound was investigated for the presence of antibodies to FVIII using activated partial time-based screening and confirmatory tests. A late acting coagulation factor inhibitor was detected. The same was characterised to be a low titre antibody against FVIII (5.2 Bethesda units). Cryoprecipitate infusions, corticosteroids and topical desmopressin were unsuccessful in controlling the bleeding. Addition of cyclophosphamide brought about stoppage of bleeding and disappearance of the autoantibody.
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