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Pathogenesis of quinolone-induced arthropathy: a review of hypotheses

T Maślanka1, J J Jaroszewski, M Chrostowska

  • 1Section of Pharmacology, Department of Pathology and Pharmacology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718 Olsztyn, Poland. tomasz.maslanka@moskit.uwm.edu.pl

Polish Journal of Veterinary Sciences
|January 7, 2005
PubMed

Insights

Quinolone antibiotics can harm cartilage in young animals. This review explores potential mechanisms, including effects on DNA, collagen, and magnesium binding, to understand quinolone-induced arthropathy.

Area of Science:

  • Pharmacology
  • Toxicology
  • Biochemistry

Background:

  • Quinolones are known to cause arthropathic effects in juvenile animals across various species.
  • Previous research has investigated quinolone mechanisms, focusing on DNA, collagen, and proteoglycan synthesis inhibition, as well as reactive oxygen species formation.

Purpose of the Study:

  • To review and summarize the proposed mechanisms underlying quinolone-induced arthropathy.
  • To consolidate current understanding of how quinolones affect cartilage development and integrity.

Main Methods:

  • Literature review of studies investigating quinolone effects on cartilage.
  • Analysis of proposed biochemical and molecular mechanisms of quinolone-induced cartilage damage.

Main Results:

  • Quinolones impact cartilage through various pathways, including inhibition of essential synthesis processes.
  • Emerging evidence suggests magnesium chelation by quinolones may play a role in arthropathy.

Conclusions:

  • The precise mechanism of quinolone-induced arthropathy remains undetermined.
  • Further research is needed to elucidate the complex interactions between quinolones and cartilage, potentially involving magnesium homeostasis.

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