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Updated: Aug 20, 2026

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
Published on: September 27, 2024
The percutaneous absorption of salicylic acid
H Takahashi1, T Ishii, K Tanabe
1Department of Dermatology, School of Medicine, Teikyo University, Kaga-2, Itabashi-ku, Tokyo 173, Japan.
Abstract:
The present paper reports on the penetration of salicylic acid, a substance with high permeability, through swine skin. Liquid scintillation counter and autoradiographic measurements were performed, on the excised swine skin to which ointment had been applied. The results indicated that the substance penetrated mainly through transfollicular route and was deposited transiently at various levels of each follicle, resulting in zig-zag pattern on the liquid scintillation counter curve. The autoradiographic study also revealed a heavy transfollicular pattern of the substance though a slight transepidermal pattern was also noted. Whether the substance penetrates because of its lipid solubility or because of its affinity to the keratinous tissue is still open to question.
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