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Rib infarcts in sickling disease.

W P Cockshott1

  • 1Department of Radiology, McMaster University Medical Centre Hamilton, Ontario, Canada.

European Journal of Radiology
|January 1, 1992
PubMed
Summary
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Radiographs reveal multiple rib infarcts in sickle cell disease patients, potentially causing acute chest syndrome. These bone lesions heal, leaving sclerosis, and may stem from azygos venous system pressure.

Area of Science:

  • Radiology
  • Hematology
  • Pathology

Background:

  • Sickle cell states can lead to various complications, including bone abnormalities.
  • Acute chest syndrome is a serious complication often attributed to lung infarcts or pneumonia.
  • The radiographic evidence of rib involvement in sickle cell disease requires further elucidation.

Purpose of the Study:

  • To document the radiographic features of multiple rib infarcts in patients with sickle cell states.
  • To explore the potential association between rib infarcts and acute chest syndrome.
  • To investigate the pathogenesis and healing process of these bone lesions.

Main Methods:

  • Radiographic analysis of patients with sickle cell states.
  • Observation of bony and extrapleural changes over time.

Related Experiment Videos

  • Correlation of radiographic findings with clinical presentation.

    • Main Results:

    • Multiple rib infarcts were identified radiographically in sickle cell patients.
    • These infarcts can be associated with or cause acute chest syndrome.
    • Extrapleural changes are detectable, and bony lesions heal with residual sclerosis.
    • Sequestra formation was not observed.
    • Azygos venous system hypertension is proposed as a potential cause.

    Conclusions:

    • Rib infarcts are a distinct radiographic finding in sickle cell states.
    • Radiography can identify these lesions and their association with acute chest syndrome.
    • The healing pattern involves sclerosis without sequestra, suggesting a unique pathogenesis possibly related to venous pressure.