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Direct Observation of Phagocytosis and NET-formation by Neutrophils in Infected Lungs using 2-photon Microscopy
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[Infection of Penicillium marneffei]

Zhao-Hui Lu1, Hong-Rui Liu, Xiu-Li Xie

  • 1Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|January 7, 2005
PubMed
Abstract

Insights

Penicillium Marneffei infection, a fungal disease common in Southeast Asia, presents with lymphadenopathy and lung issues. Early diagnosis and antifungal treatment are crucial for recovery, especially in immunocompromised individuals.

Area of Science:

  • Medical Mycology
  • Infectious Diseases

Background:

  • Penicillium Marneffei is a dimorphic fungus endemic to Southeast Asia.
  • Infection can affect both healthy and immunocompromised individuals, including those with Human Immunodeficiency Virus (HIV).

Observation:

  • Common clinical manifestations include lymphadenopathy and pulmonary involvement.
  • Histopathological findings reveal granulomatous, suppurative, or anergic/necrotic lesions.
  • The fungus is typically found within macrophages, identifiable with Periodic Acid-Schiff (PAS) and Giemsa stains.

Findings:

  • Penicillium Marneffei is a temperature-sensitive fungus.
  • Diagnosis is confirmed by observing a characteristic wine-red color on culture.
  • Differential diagnosis includes tuberculosis and histoplasmosis.

Implications:

  • Early detection and treatment of Penicillium Marneffei infection are vital for patient outcomes.
  • Consideration of this infection is important in endemic areas, particularly with suspected tuberculosis.
  • Prompt initiation of antifungal therapy improves recovery rates.

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