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Related Experiment Videos

The facts and controversies about selenium.

Slavica Dodig1, Ivana Cepelak

  • 1Special Hospital for Respiratory Diseases in Children and Adolescents, Zagreb, Croatia. bolnica_srebrnjak@yahoo.com

Acta Pharmaceutica (Zagreb, Croatia)
|January 7, 2005
PubMed
Summary

Selenium is an essential trace element vital for selenoproteins, immune function, and overall health. Further research is needed, but studies suggest selenium supplementation may offer preventive and therapeutic benefits for various diseases.

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Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • Selenium is an essential trace element crucial for human and animal health.
  • Its bodily levels are primarily determined by dietary intake, influenced by soil selenium content.
  • Over 30 selenoproteins, including key enzymes, rely on selenium for their function.

Purpose of the Study:

  • To review the essential role of selenium in biological functions.
  • To explore the supportive role of selenium in various health conditions and diseases.
  • To highlight the potential preventive and therapeutic applications of selenium supplementation.

Main Methods:

  • Literature review of existing clinical examinations and studies on selenium's role in health and disease.
  • Analysis of the known functions of selenoproteins.

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  • Examination of research on selenium supplementation's effects.

    • Main Results:

    • Selenium is vital for over 30 selenoproteins, impacting immune and thyroid function, metabolism, and bodily defense.
    • Clinical studies suggest selenium supplementation may play a preventive and therapeutic role in conditions such as male infertility, viral infections (including HIV), cancer, cardiovascular diseases, and autoimmune diseases.
    • Investigations in Croatia suggest a potential for inadequate selenium status in the local population.

    Conclusions:

    • Selenium is indispensable for numerous physiological processes and maintaining health.
    • Selenium supplementation shows promise as a preventive and therapeutic strategy for a range of diseases.
    • Further research is warranted to definitively establish selenium's therapeutic roles and mechanisms of action, especially considering potential regional deficiencies.