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Downregulation of messenger RNA levels for ribosomal proteins in differentiating HL-60 cells
R Mailhammer1, H Szöts, J Bönisch
1GSF-Institut für Experimentelle Hämatologie, München, Germany.
Experimental Cell Research
|May 1, 1992
Abstract:
After differentiation induction in HL-60 cells by treatment with retinoic acid, phorbol ester, or dimethyl sulfoxide strong downregulation of the steady state mRNA level of the putative protein No. 3 of the large ribosomal subunit (rpL3) was observed. Downregulation was also observed in other hemopoietic human cell lines, although to a lesser extent. Four ribosomal protein mRNAs were compared in their degree of downregulation after differentiation induction or actinomycin D treatment. The comparatively fast response of rpL3 mRNA observed could indicate a regulatory function of rpL3 protein.