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Related Experiment Videos

Hypercalcemia caused by iatrogenic hypervitaminosis A.

Karan Bhalla1, David M Ennis, Elizabeth D Ennis

  • 1Baptist Health System, 840 Montclair Rd, Suite 317, Birmingham, AL 35213, USA. karan.bhalla@bhsala.com

Journal of the American Dietetic Association
|January 7, 2005
PubMed
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High vitamin A intake from enteral formulas can cause rare hypercalcemia. Reducing vitamin A in the diet resolved the patient's asymptomatic hypercalcemia and normalized vitamin A levels.

Area of Science:

  • Clinical Medicine
  • Nutritional Science
  • Toxicology

Background:

  • Vitamin A toxicity can manifest in various ways, affecting multiple organ systems.
  • Hypercalcemia is a rare but documented complication of elevated vitamin A levels.

Observation:

  • A patient on a commercial enteral feeding formula for two years developed asymptomatic hypercalcemia.
  • The patient's serum vitamin A levels were significantly elevated, several times the normal range.

Findings:

  • Switching to a custom enteral feed with negligible vitamin A content led to a substantial decrease in serum vitamin A levels.
  • Concurrently, the patient's serum calcium levels returned to normal, resolving the hypercalcemia.

Implications:

Related Experiment Videos

  • This case highlights the potential for vitamin A toxicity from long-term enteral nutrition.
  • It underscores the importance of monitoring vitamin A levels and adjusting nutritional support in patients receiving long-term enteral feeding.
  • This suggests that specific enteral formulas may contribute to vitamin A toxicity and associated hypercalcemia.