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[Hemorheological parameters in isolated obesity].

C Le Devehat1, T Khodabandehlou, M Dougny

  • 1Unité de Recherches d'Hémorhéologie clinique, Centre Hospitalier, Nevers, France.

Diabete & Metabolisme
|January 1, 1992
PubMed
Summary

Obesity significantly increases red blood cell aggregation and decreases their deformability, impacting blood flow. These hemorheological changes, linked to altered plasma proteins, may contribute to vascular disease risk in obese individuals.

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Clinical hemorheology and microcirculation·2004

Area of Science:

  • Physiology
  • Hematology
  • Vascular Biology

Context:

  • Obesity is a known risk factor for thrombosis and vascular diseases.
  • Previous studies on hemorheological disturbances in obesity were often confounded by comorbidities.
  • This study isolates the effects of obesity on blood rheology in the absence of other pathologies.

Purpose:

  • To investigate the impact of obesity on blood rheological properties.
  • To determine if obesity alone alters erythrocyte aggregation and deformability.
  • To identify associated changes in plasma viscosity and protein levels.

Summary:

  • Obese individuals exhibited significantly increased erythrocyte aggregation compared to controls.
  • Red blood cell deformability was significantly decreased in the obese group.
  • Increased plasma viscosity and fibrinogen, with decreased albumin, were observed in obese subjects.

Impact:

  • Obesity-induced alterations in plasma proteins (fibrinogen, albumin) appear to drive changes in erythrocyte aggregation.
  • These rheological disturbances due to excess weight may represent a significant risk factor for vascular diseases.
  • Findings highlight the direct link between obesity and detrimental changes in blood rheology.

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