Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Optic nerve damage in multiple sclerosis patients].

Marek Rekas1, Rafał Pawlik, Joanna Wierzbowska

  • 1Kliniki Okulistycznej Wojskowego Instytutu Medycznego w Warszawie.

Klinika Oczna
|January 8, 2005
PubMed
Summary

Psychophysical tests identified distinct patterns of optic nerve damage in multiple sclerosis patients. These methods aid in the early diagnosis and monitoring of visual impairment in multiple sclerosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Five-Year Outcomes of First-Generation iStent Versus Hydrus Microstent Implantation Combined with Phacoemulsification in Patients with Open-Angle Glaucoma: A Prospective Non-Randomized Comparative Study.

Journal of clinical medicine·2026
Same author

The Pathophysiological Association Between Obstructive Sleep Apnea and Glaucoma: A Current Update.

Journal of clinical medicine·2026
Same author

Sutureless capsular bag-intraocular lens complex scleral fixation using iris retractors in eyes with crystalline lens subluxation: long-term outcome.

Scientific reports·2026
Same author

Long-Term Assessment of Intraocular Lens Stability, Tilt and Decentration Between Four-Point Scleral Fixation and Yamane Techniques.

Journal of clinical medicine·2026
Same author

Impact of Flap Thickness on Refractive Outcomes and Corneal Biomechanics Following Myopic Femtosecond Laser-Assisted LASIK.

Journal of clinical medicine·2026
Same author

An update on posterior-approach blepharoptosis surgery: Influence of clinical factors on surgical outcomes.

PloS one·2026

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Multiple sclerosis (MS) frequently affects the optic nerve, leading to visual dysfunction.
  • Early detection of optic nerve damage is crucial for managing MS progression.
  • Optic neuritis is a common initial symptom in MS, but subclinical damage also occurs.

Purpose of the Study:

  • To characterize the types of optic nerve damage in patients with multiple sclerosis using psychophysical tests.
  • To investigate the relationship between contrast sensitivity, color vision, and MS-related optic nerve pathology.

Main Methods:

  • Evaluated 77 eyes from 40 multiple sclerosis patients using the CSV-1000 contrast test and anomaloscopy (AN-69).
  • Assessed contrast sensitivity function and color perception (red, green, blue hue thresholds).
  • Categorized eyes into selective and non-selective damage groups based on psychophysical test results.

Main Results:

  • Identified selective damage in 11.7% of eyes, characterized by reduced contrast sensitivity and altered blue or red hue perception.
  • Found non-selective damage in 77.9% of eyes, showing decreased contrast sensitivity with a tendency towards high spatial frequency impairment.
  • Observed specific patterns, including increased blue hue threshold and potential protanomaly, correlating with contrast sensitivity deficits.

Conclusions:

  • Psychophysical tests, including contrast sensitivity and color vision assessment, are valuable tools for diagnosing optic nerve damage in MS.
  • These methods facilitate early detection and ongoing monitoring of visual pathway involvement in multiple sclerosis.
  • The findings highlight the utility of psychophysical assessments in understanding the spectrum of optic nerve pathology in MS.

Related Experiment Videos