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Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
Surgical management of cartilage defects in athletes
Paul K Ritchie1, Eric C McCarty
1University of Colorado School of Medicine, Department of Orthopaedics, CU Sports Medicine and Shoulder Surgery, 311 Mapleton Avenue, Boulder, CO 80304, USA.
Abstract:
The synovial joints provide a unique environment in which to carry out their critical mechanical function. The complex architecture of the articular cartilage normally provides painless motion throughout a variety of activities. Fluids secreted by cells in the superficial layers of the articular cartilage as well as in the synovium provide an almost frictionless articulation. The synovium also helps to maintain the aseptic environment found within the joint. The cartilage and fluid provide critical protection to the underlying bone. If any of these structures are damaged, or lose their efficiency, the ensuing cascade of damage inflicted on the joint can lead to catastrophic failure.

