Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Flow cytometry as a predictive modality in prostate cancer.

A D Deitch1, R W deVere White

  • 1Department of Urology, University of California, Davis, Sacramento.

Human Pathology
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer.

Oncogene·2017
Same author

Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model.

Oncogene·2014
Same author

miR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT.

Oncogene·2013
Same author

Tumor suppressive miR-124 targets androgen receptor and inhibits proliferation of prostate cancer cells.

Oncogene·2012
Same author

Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples.

Advances in virology·2012
Same author

Prognostic significance of DNA ploidy in Ta/Tl bladder cancer: A southwest oncology group study.

Urologic oncology·2011

DNA flow cytometry provides prognostic information for prostate cancer, but its clinical value for individual patients is limited. Ploidy analysis does not predict survival or response to radiation but may indicate tumor changes after treatment.

Area of Science:

  • Oncology
  • Urology
  • Genetics

Background:

  • Clinical staging and histologic grading have limited predictive value for prostate cancer treatment response.
  • Existing prognostic tools for prostate cancer are insufficient for personalized therapy decisions.

Purpose of the Study:

  • To evaluate the additional prognostic information provided by DNA flow cytometry in prostate cancer.
  • To assess the utility of DNA flow cytometry in predicting treatment response, survival, and tumor behavior.

Main Methods:

  • Review of findings from a large prospective study of patients with localized and locally advanced prostate cancer.
  • Retrospective analysis of flow cytometric studies examining specific disease stages.
  • Correlation of ploidy abnormalities with clinical outcomes and tumor characteristics.

Related Experiment Videos

Main Results:

  • DNA flow cytometry offers additional prognostic information beyond traditional methods.
  • Ploidy does not reliably predict survival in disseminated prostate cancer or benefit from radiation therapy for localized disease.
  • Increased ploidy abnormalities are frequently observed in persistent tumors post-radiation.
  • DNA flow cytometry can predict tumor volume and identify "field effects" through proliferation in adjacent tissues.

Conclusions:

  • DNA flow cytometry provides valuable insights into the natural history and biologic behavior of prostate cancer.
  • While offering prognostic data, the individual patient value of DNA flow cytometry requires further clinical correlation.
  • Ploidy analysis may reveal treatment-induced changes and field effects in prostate cancer.