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Related Experiment Videos

Autistic-like behavior in CHARGE syndrome.

Timothy S Hartshorne1, Tina L Grialou, Kellie R Parker

  • 1Psychology Department, Central Michigan University, Mount Pleasant, Michigan 48859, USA. tim.hartshorne@cmich.edu

American Journal of Medical Genetics. Part A
|January 8, 2005
PubMed
Summary
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Children with CHARGE syndrome display unique autistic-like behaviors, differing from those seen in autism or deafblindness. These behaviors are not fully explained by autism or deafblindness alone.

Area of Science:

  • Developmental Psychology
  • Clinical Psychology
  • Genetics

Background:

  • Children with CHARGE syndrome often present with moderate to severe behavioral challenges.
  • Previous research indicated behaviors associated with autism, attention deficit disorder, Tourette syndrome, and obsessive-compulsive disorder in CHARGE syndrome.
  • Some behaviors in CHARGE syndrome overlap with those typical of deafblind individuals.

Purpose of the Study:

  • To investigate if autistic-like behaviors in CHARGE syndrome are more similar to those in autism, deafblindness, or if they are unique to CHARGE syndrome.
  • To compare the behavioral profiles of children with CHARGE syndrome to established norms for autism and deafblindness.

Main Methods:

  • A survey including the Autism Behavior Checklist (ABC) was administered to families of 204 children with CHARGE syndrome.

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  • 160 usable surveys were collected, representing a 78% response rate.
  • Total and subscale scores on the ABC were analyzed and compared to normative data.

    • Main Results:

    • Total Autism Behavior Checklist (ABC) scores for children with CHARGE syndrome were significantly different from autism and deafblind norms.
    • The variance in ABC scores was larger for the CHARGE syndrome group compared to normative groups.
    • 27.5% of children with CHARGE syndrome met the criteria for autism based on ABC scores, and the pattern of subscale scores differed from other groups.

    Conclusions:

    • Autistic-like behaviors in CHARGE syndrome are distinct and do not perfectly align with autism or deafblindness classifications.
    • While some children with CHARGE syndrome exhibit autistic behaviors, the overall behavioral pattern is unique to the syndrome.
    • Further research is needed to understand the specific behavioral phenotype of CHARGE syndrome.