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A sampling device for septum-sealed blood containers.

M D Isaacs1, N Dunnett, D J Nicholson

  • 1Home Office Forensic Science Laboratory, Aldermaston, Berks RG7 4PN.

Annals of Clinical Biochemistry
|September 1, 1975
PubMed
Summary

A new device prevents blood sample contamination and operator exposure by enabling sealed vial sampling. This automated diluter probe eliminates volatile loss and enhances laboratory safety.

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Area of Science:

  • Biochemistry
  • Laboratory Automation
  • Analytical Chemistry

Background:

  • Automatic diluters are crucial for sample preparation in various analytical procedures.
  • Current methods using sampling probes can lead to sample contamination and operator exposure.
  • Loss of volatile compounds during open-system sampling can affect analytical accuracy.

Purpose of the Study:

  • To introduce a novel device that replaces the standard sampling probe of automatic diluters.
  • To enable the direct sampling of blood from septum-sealed vials.
  • To prevent atmospheric exposure of blood samples during the dilution process.

Main Methods:

  • The device integrates with existing automatic diluter systems.
  • It utilizes a mechanism to access blood within septum-sealed vials.

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  • Dispensing occurs directly into sealed reaction vials, maintaining sample integrity.

    • Main Results:

    • The device successfully samples blood from sealed vials without atmospheric exposure.
    • Elimination of volatile compound loss from the blood sample was achieved.
    • Operator exposure to open blood containers was completely prevented.

    Conclusions:

    • This innovative device enhances the safety and accuracy of automated sample preparation.
    • It offers a significant improvement over traditional sampling probes for volatile-containing liquid samples.
    • The technology is applicable to various laboratory settings requiring precise and safe liquid handling.