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Enteroaggregative Escherichia coli strains secrete a heat-labile toxin antigenically related to E. coli hemolysin
T J Baldwin1, S Knutton, L Sellers
1Department of Genetics, University of Leicester, United Kingdom.
Infection and Immunity
|May 1, 1992
Abstract:
A protein toxin of approximately 120,000 Da secreted by nonhemolytic enteroaggregative Escherichia coli strains cross-reacted in Western blots (immunoblots) with antibodies raised against the C-terminal region of E. coli hemolysin. Treatment of HEp-2 cells with enteroaggregative E. coli or culture supernatants caused elevation of intracellular calcium and stimulated calcium-dependent protein phosphorylation.