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[Differentially expressed genes in prostate cancer and benign prostatic hyperplasia]
Tong Zhang1, Yong Xu, Hua Tang
1Department of Urology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China.
Zhonghua Nan Ke Xue = National Journal of Andrology
|January 11, 2005
Abstract
Objective:
To detect and analyze the differentially expressed genes in prostate cancer (PCa) and benign prostatic hyperplasia (BPH).
Methods:
Oligonucleotide microarray containing 465 genes was used to investigate the differentially expressed genes in PCa and BPH.
Results:
There were 35 differentially expressed genes between PCa and BPH, of which 17 were up-regulated and 18 down-regulated in PCa.
Conclusion:
The study of the differentially expressed genes in PCa and BPH should help to understand the molecular mechanism of PCa and identify the markers for diagnostic and therapeutic use.