Transdermal microparticle delivery by a supersonic-Helios gun system
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Updated: Aug 20, 2026

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Published on: January 28, 2021
1College of Pharmaceutical Sciences, Zhejang University, Zhejiang University, Hangzhou, China. jinyizju@hotmail.com
Abstract:
The effect of particle size and flow of helium gas on the systemic absorption of indomethacin by means of a needle-free injection system was investigated. Poly-L-lactic acid microspheres conaining indomethacin were prepared by the o/w solvent evaporation technique. Microspheres were accelerated by a stream of helium gas in the Helios gun system, and then delivered to the abdominal skin of male hairless rats. Delivery of indomethacin to rat skin proportionally increased with helium pressure (supersonic flow). Bioavailability and Cmax were also dependent on the helium pressure. This method can be used to deliver the drug and/or microparticulate systems into the skin tissues and systemic circulation.
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