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Related Experiment Videos

Mast cell--pituitary interaction: modulation by serine phospholipids.

G Viola1, E Galbiati

  • 1Department of Pharmaceutical Sciences, University of Padova, Italy. giampietro.viola.1@unipd.it

Die Pharmazie
|January 11, 2005
PubMed
Summary

Lysophosphatidylserine triggers prolactin secretion via mast cell activation in rats. This effect is histamine-dependent and can be modulated by dopamine, impacting prolactin levels.

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Area of Science:

  • Endocrinology
  • Neuroimmunology
  • Cell Biology

Background:

  • Mast cells play a role in regulating hormone secretion.
  • Lysophosphatidylserine is a phospholipid with known secretagogue activity.
  • The interaction between mast cells and the pituitary gland in hormone regulation is not fully understood.

Purpose of the Study:

  • To investigate the influence of mast cell activation by lysophosphatidylserine on prolactin secretion in rats.
  • To elucidate the role of histamine in lysophosphatidylserine-induced prolactin release.
  • To examine the long-term effects of repeated lysophosphatidylserine administration on prolactin levels and pituitary function.

Main Methods:

  • Intravenous injection of lysophosphatidylserine in rats.
  • Measurement of plasma prolactin and blood histamine levels.

Related Experiment Videos

  • Inhibition studies using H1 antihistamine (tripelenamine).
  • In vitro experiments with isolated rat pituitaries and lysophosphatidylserine derivatives.
  • Assessment of pituitary prolactin stores.

    • Main Results:

    • Lysophosphatidylserine administration caused a peak in plasma prolactin correlating with increased blood histamine.
    • Histamine release and prolactin secretion were inhibited by tripelenamine.
    • Repeated lysophosphatidylserine administration led to mast cell desensitization and reduced pituitary response.
    • In vitro, diacyl lysophosphatidylserine amplified dopamine's inhibitory effect on prolactin secretion.

    Conclusions:

    • Lysophosphatidylserine induces prolactin secretion primarily through mast cell activation and subsequent histamine release.
    • The pituitary's response to lysophosphatidylserine is subject to desensitization with repeated exposure.
    • Post-secretory reacylation of lysophosphatidylserine in pituitary membranes may enhance dopamine's inhibitory control over prolactin secretion.