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Updated: Aug 20, 2026

Curtain Flow Column: Optimization of Efficiency and Sensitivity
Published on: June 12, 2016
An experimental study of chromatographic dynamics in open and packed non-cylindrical conduits
Gerard Rozing1, Tom van de Goor, Hongfeng Yin
1Agilent Technologies Inc, Palo Alto, CA, USA. gerard_rozing@agilent.com
Abstract:
A systematic investigation of the influence of the perimeter shape of open and particle packed fused silica capillaries on chromatographic properties such as resistance to flow and dispersion of solutes propelled through these channels has been conducted. Verifications of these uncommon experiments with existing theoretical treatments are presented and the insights transferred to a novel polymer chip design with integrated facilities for complex separations. A comparison of the chromatographic performance of a real life proteomics sample on this chip with a capillary column of "similar" dimensions is presented.
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