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Updated: Aug 20, 2026

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
Published on: October 21, 2017
Study on carcinogenesis in chronic cholecystitis
L Zimnoch1, B Szynaka, A Kupisz
1Department Medical Pathomorphology, Medical University of Białystok, Poland. lech@amb.edu.pl
Abstract:
Not only bile but also chronic cholecystitis may play a role in gallbladder carcinogenesis. Numerous studies have revealed a close correlation between chronic inflammation and neoplasia. The experiments were conducted on paraffin sections, obtained from 377 surgically resected gallbladders with chronic cholecystitis. Immunohistochemical reaction was conducted on deparaffinized sections, using a monoclonal antibody against 8-hydroxydeoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage. An increase was found in the expression of 8-hydroxydeoxyguanosine in chronic cholecystitis. The level of 8-OhdG expression is associated with inflammation intensity and disease duration. DNA damage, observed in chronic cholecystitis, indicates a correlation between chronic inflammation and gallbladder carcinogenesis.
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