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Related Experiment Video

Updated: Jun 30, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Overlapping messages and survivability.

Ofer Peleg¹, Valery Kirzhner, Edward Trifonov

¹Genome Diversity Center, Institute of Evolution, Haifa University Mt Carmel, Haifa 31905, Israel. peleg@research.haifa.ac.il

Journal of Molecular Evolution

|January 11, 2005

Summary

Genome sequence message overlapping, possible due to codon degeneracy, offers a direct evolutionary advantage. This occurs because reducing vulnerable points in overlapping sequences outweighs the cost of message coexistence.

Related Experiment Videos

Last Updated: Jun 30, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Area of Science:

Genomics
Evolutionary Biology
Molecular Genetics

Background:

Genome sequence message overlapping is a puzzle for researchers, observed in organisms with small genomes and low-fidelity polymerases.
The prevailing view is that overlapping increases information density per unit length.
Codon degeneracy is a key factor enabling message overlapping.

Purpose of the Study:

To present a model explaining the direct evolutionary advantage of message overlapping.
To analyze the opposing evolutionary drives influencing message overlapping.

Main Methods:

Modeling the evolutionary dynamics of overlapping sequences.
Analyzing two opposing drives: reduction of vulnerable points and cumulative compromising cost.
Evaluating conditions under which overlapping becomes advantageous.

Main Results:

The model demonstrates a direct evolutionary advantage for message overlapping.
Reduction in the amount of vulnerable points is a significant factor.
The reduction of target size generally prevails over compromising costs.

Conclusions:

Message overlapping provides a direct evolutionary benefit.
The advantage is primarily driven by the reduction of vulnerable genomic sites.
Overlapping sequences are evolutionarily favored under a broad range of conditions.