Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ultrathin antibiotic walled microcapsules.

Ajay J Khopade1, N Arulsudar, Surekha A Khopade

  • 1Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, D-14476 Golm, Germany. ajkhopade@sunpharma.com

Biomacromolecules
|January 11, 2005
PubMed
Summary

Ultrathin antibiotic microcapsules were developed using layer-by-layer assembly for sustained ophthalmic drug delivery. These polyelectrolyte/aminoglycoside capsules demonstrate safety and efficacy in vivo.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preclinical Toxicity and Pharmacokinetic Evaluation of Paclitaxel Nanodispersion.

AAPS PharmSciTech·2025
Same author

Development of Paclitaxel Injection Concentrate for Nanodispersion.

AAPS PharmSciTech·2025
Same author

Antitumor Efficacy of Paclitaxel Injection Concentrate for Nanodispersion in Patient-Derived Breast, Head and Neck, and Non-Small Cell Lung Cancer Mouse Xenografts.

AAPS PharmSciTech·2025
Same author

Aminoglycoside/Hexadecanoic Acid Complex Lamellar Core Nanoparticles.

ACS omega·2025
Same author

A Novel Self-Assembled Paclitaxel Nanodispersion Facilitates Rapid In-Vitro/In-Vivo Dissociation and Protein Binding.

AAPS PharmSciTech·2024
Same author

A Comparative Preclinical Evaluation of a Novel Difluprednate 0.04% BID Ophthalmic Solution and Marketed 0.05% QID Ophthalmic Emulsion.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics·2023

Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Science

Background:

  • Developing novel drug delivery systems is crucial for improving therapeutic outcomes.
  • Ultrathin microcapsules offer potential for targeted and sustained drug release.
  • Aminoglycoside antibiotics are vital for treating bacterial infections, but require effective delivery methods.

Purpose of the Study:

  • To prepare and characterize ultrathin microcapsules composed of polyelectrolytes and an aminoglycoside antibiotic.
  • To evaluate the stability, drug loading, and decomposition kinetics of these microcapsules.
  • To assess the in vivo safety and sustained drug delivery potential of the microcapsules for ophthalmic applications.

Main Methods:

  • Layer-by-layer self-assembly of anionic polyelectrolytes (dextran sulfate sodium or poly(styrenesulfonate)) and tobramycin sulfate on zinc oxide cores.

Related Experiment Videos

  • Dissolution of zinc oxide cores to yield hollow microcapsules.
  • Characterization using zeta potential measurements, transmission and scanning electron microscopy, quartz crystal microbalance, and high-performance liquid chromatography.
  • In vivo studies in rabbits to evaluate safety and drug delivery.

    • Main Results:

    • Successfully fabricated ultrathin polyelectrolyte/tobramycin sulfate microcapsules via layer-by-layer assembly on ZnO templates.
    • Microcapsule yield varied based on polyelectrolyte choice (PSS/TbS higher than DxS/TbS).
    • Decomposition rates differed in various media, with physiological buffer showing the fastest breakdown; stability was influenced by hydrogen bonding and hydrophobic interactions.
    • In vivo studies confirmed the safety and sustained drug delivery capabilities of the microcapsules.

    Conclusions:

    • Ultrathin polyelectrolyte/aminoglycoside microcapsules can be effectively prepared using layer-by-layer assembly and ZnO templating.
    • The physicochemical properties of the polyelectrolytes influence capsule formation and stability.
    • These microcapsules show promise for sustained ophthalmic antibiotic delivery due to their safety and controlled release characteristics.