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Observations on EEG patterns in neurally-mediated syncope: an inspective and quantitative study.

O Mecarelli1, P Pulitano, E Vicenzini

  • 1Department of Neurological Sciences, La Sapienza University, Viale Regina Elena, 336, 00161 Rome, Italy. oriano.mecarelli@uniroma1.it

Neurophysiologie Clinique = Clinical Neurophysiology
|January 11, 2005
PubMed
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Electroencephalogram (EEG) abnormalities are common in neurally-mediated syncope patients, even at rest. Hyperventilation provokes distinct EEG changes in syncopal patients, differing from healthy controls.

Area of Science:

  • Neuroscience
  • Clinical Neurology

Background:

  • Neurally-mediated syncope is a common condition.
  • Electroencephalogram (EEG) findings in syncope are not fully understood.

Purpose of the Study:

  • To investigate EEG characteristics in patients with neurally-mediated syncope.
  • To compare EEG findings between syncopal patients and healthy controls at rest and during hyperventilation.

Main Methods:

  • Observational study involving 43 syncope patients and 32 healthy controls.
  • EEG recordings were performed at basal condition and during hyperventilation (HV).
  • Blind analysis included visual inspection and quantitative spectral analysis.

Main Results:

  • At rest, 47% of syncope patients had abnormal EEGs compared to 94% of controls (P < 0.001).

Related Experiment Videos

  • Patients showed more delta-theta activities and alpha slowing than controls.
  • During HV, 40% of syncopal patients exhibited "pseudoparoxysmal" rhythmic delta activity, not seen in controls.
  • Conclusions:

    • Abnormal EEG findings, including specific slow activities and pseudoparoxysmal patterns during HV, are common in neurally-mediated syncope.
    • These EEG changes are distinct from those seen in healthy adults and epileptiform activity.
    • Further research is needed to elucidate the pathophysiology of these EEG modifications in syncope.