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[Lupus nephritis: 211 cases].

S Béji1, H Kaaroud, F Ben Moussa

  • 1Service de néphrologie et de médecine interne, hôpital Charles-Nicolle, boulevard du 9-avril-1938, 1006 BS Tunis, Tunisie. soumaya.beji@rns.tn <soumaya.beji@rns.tn>

La Revue De Medecine Interne
|January 11, 2005
PubMed
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Systemic lupus erythematosus can severely affect kidneys, leading to lupus nephritis. Younger age, hypertension, nephrotic syndrome, and initial renal failure are key indicators of poor prognosis in lupus nephritis patients.

Area of Science:

  • Nephrology
  • Rheumatology
  • Immunology

Context:

  • Systemic lupus erythematosus (SLE) frequently involves the kidneys, presenting as lupus nephritis.
  • Prognostic factors for lupus nephritis outcomes vary across studies.
  • Understanding these factors is crucial for managing this severe SLE manifestation.

Purpose:

  • To analyze the clinical, biological, and histological characteristics of lupus nephritis in 211 patients.
  • To identify prognostic factors associated with disease progression and outcomes.
  • To evaluate treatment responses and long-term outcomes in a cohort of lupus nephritis patients.

Summary:

  • This retrospective study analyzed 211 lupus nephritis patients (195 female, 16 male; mean age 28.8 years) between 1975 and 2003.

Related Experiment Videos

  • Initial presentations included hypertension (32.3%), nephrotic syndrome (47.7%), and renal failure (51.6%). Histological classes were III (59), IV (97), and V (33).
  • After a mean follow-up of 103 months, 55.3% achieved remission, 34.8% experienced renal function deterioration, 14.7% reached end-stage renal failure, and 51% had relapses. Age <24, hypertension, nephrotic syndrome, and initial renal failure were linked to deterioration.

    • Impact:

    • Identifies critical prognostic factors for lupus nephritis, including age, hypertension, nephrotic syndrome, and initial renal failure.
    • Highlights the high prevalence of severe proliferative lupus nephritis forms in the studied cohort.
    • Provides insights into long-term outcomes and relapse rates, informing clinical management strategies for lupus nephritis.