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Updated: Aug 20, 2026

DetectSyn: A Rapid, Unbiased Fluorescent Method to Detect Changes in Synapse Density
Published on: July 22, 2022
Brain plasticity and antidepressant treatments: new cells, new connections
Ian C Reid1, Caroline A Stewart
1Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.
Abstract:
It is now a decade since we first wrote about the impact of antidepressant agents on plastic processes in the hippocampus (Stewart and Reid, 1993). Since then, the roles of various forms of brain plasticity have moved centre stage in efforts to understand the pathophysiology of depressive disorder. Here, we review the background to current views relating cytoarchitectural and synaptic changes to the aetiology and treatment of affective disease.
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