Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The evolution and application of microsatellites].

Wen-Yong Luo1, Jun Hu, Xiao-Fang Li

  • 1The Key Laboratory of Gene Engineering of Ministry of Education, Zhongshan University, Guangzhou 510275, China. wenyongluo@yahoo.com

Yi Chuan = Hereditas
|January 11, 2005
PubMed
Summary

Microsatellites, or simple sequence repeats (SSRs), are common DNA sequences that easily change length during replication. Their high polymorphism makes them valuable for genetic analysis and breeding.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A comparative study on inhibition of total astragalus saponins and astragaloside IV on TNFR1-mediated signaling pathways in arterial endothelial cells.

PloS one·2014
Same author

Recognition kinetics of biomolecules at the surface of different-sized spheres.

Biophysical journal·2014
Same author

A supercharged fluorescent protein as a versatile probe for homogeneous DNA detection and methylation analysis.

Angewandte Chemie (International ed. in English)·2014
Same author

Radiation-induced removal of sulphadiazine antibiotics from wastewater.

Environmental technology·2014
Same author

Effect of Methyl-CpG binding domain protein 2 (MBD2) on AMD-like lesions in ApoE-deficient mice.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban·2014
Same author

Overexpression of TRPM7 is associated with poor prognosis in human ovarian carcinoma.

Asian Pacific journal of cancer prevention : APJCP·2014

Area of Science:

  • Genomics
  • Molecular Biology

Context:

  • Microsatellites, also known as simple sequence repeats (SSRs), are abundant in eukaryote genomes.
  • Their sequence content and types vary across different organisms.

Purpose:

  • To explain the origin and mutation mechanisms of microsatellites.
  • To highlight the characteristics and applications of microsatellites in various fields.

Summary:

  • Microsatellites are prone to expansion during DNA replication, likely due to DNA slippage, with origins possibly stemming from pro-microsatellites and random mutations.
  • Despite mutations, microsatellite lengths are generally conserved during species evolution.

Impact:

  • Microsatellites serve as valuable genetic markers due to their abundance, codominance, genomic distribution, and high polymorphism.

Related Experiment Videos

  • Applications include gene mapping, clinical diagnostics, paternity testing, evolutionary studies, and marker-assisted breeding.