Related Experiment Video
Updated: Jan 9, 2026
08:34
Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay
Published on: July 15, 2025
630
[Advance on insulin-like growth factor 2]
Si-Wen Jiang1, Jian Peng, Yuan-Zhu Xiong
1College of Animal Science and Technology, Huanzhong Agricultural University, Wuhan 430 070, China. jiangsiwen@hotmail.com
Yi Chuan = Hereditas
|January 11, 2005
Summary
Insulin-like growth factor 2 (IGF2) gene structures and genomic imprinting in mammals are reviewed. IGF2 is a key gene influencing fetal development, tumor growth, and muscle mass, primarily through paternal expression.
Area of Science:
- Genomics
- Developmental Biology
- Molecular Biology
Context:
- Insulin-like growth factors (IGFs) are crucial for mammalian development.
- Genomic imprinting regulates gene expression based on parental origin.
- IGF2 is implicated in fetal growth, cell proliferation, and muscle development.
Purpose:
- To review the gene structures of insulin-like growth factor 2 (IGF2).
- To discuss the genomic imprinting of IGF2 in mammalian genomes.
- To highlight IGF2's role as a candidate gene for muscle mass determination.
Summary:
- This review examines the structural organization of the IGF2 gene.
- It details the mechanisms and patterns of IGF2 genomic imprinting across mammalian species.
- Evidence supporting IGF2 as a major paternally expressed gene influencing skeletal muscle growth is presented.
Impact:
- Provides a comprehensive overview of IGF2 gene structure and imprinting.
- Enhances understanding of the genetic basis for muscle growth regulation.
- Offers insights into the developmental roles of imprinted genes.
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