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Updated: Aug 20, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 6, 2010
[Exploration of the hidden layers of genome]
Geng-Sheng Cao1, Ai-Lian Liu, Ning Li
1State Key Laboratories of Agrobiotechnology, China Agricultural University, Beijing 100 094, China. gscao@henu.edu.cn
Abstract:
In recent years, geneticists have been exploring the less visible parts of genome more thoroughly. They are coming to realize that these much more layers of genomic information, distinct from the protein-coding genes, connect in surprisingly deep and potent ways to growth and development in the high eukaryotes. This article reviews a number of startling observations about the extent of non-protein-coding RNA transcriptions, DNA methylation and covalent histone modifications in the complex organisms.
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