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Elastomechanical characterization of brain tissues.

K B Sahay1, R Mehrotra, U Sachdeva

  • 1Center for Biomedical Engineering, Indian Institute of Technology, New Delhi.

Journal of Biomechanics
|March 1, 1992
PubMed
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This study models brain tissue mechanics using a hollow spherical shell to understand intracranial pressure changes. The elastomechanical properties were evaluated, showing satisfactory agreement with experimental data at higher inflation levels.

Area of Science:

  • Biomechanics
  • Neuroscience
  • Materials Science

Background:

  • Intracranial pressure (ICP) changes are influenced by brain tissue elastomechanics.
  • Understanding these properties is crucial for clinical implications.

Purpose of the Study:

  • To model and evaluate the elastomechanical characteristics of brain tissues.
  • To correlate fluid infusion volumes with intracranial pressure changes.

Main Methods:

  • A nonlinear hyperelastic hollow spherical shell model was used.
  • The Hart-Smith strain energy function derived constitutive equations.
  • Fluid infusion experiments were conducted in 10 dogs, recording ventricular fluid pressure (VFP) and epidural pressure (EDP).

Main Results:

Related Experiment Videos

  • Pressure-volume curves exhibited a non-monotonic behavior with maximum and minimum pressure points.
  • Maximum pressure (pv max) was 42.4 ± 15.4 mmHg with 0.19 ± 0.09 ml infusion.
  • Minimum pressure (pv min) was 33.1 ± 12.2 mmHg with 0.51 ± 0.15 ml infusion.

Conclusions:

  • The Hart-Smith model provided a satisfactory fit to experimental pressure-volume curves at high inflation levels.
  • Model-experiment agreement was less precise at lower inflation levels, suggesting limitations in the current model for representing brain tissue behavior across all volume changes.