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High-performance liquid chromatographic method for the analysis of Oltipraz in human serum and urine
J L Bennett1, J McMillan, N V Dimitrov
1Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824-1317.
Journal of Chromatography
|January 3, 1992
Abstract:
A rapid, sensitive procedure for the analysis of Oltipraz in serum and urine using high-performance liquid chromatography was developed. The proposed method illustrates recovery of Oltipraz from biological fluids was greater than 80%. Detection and separation of Oltipraz required as little as 1 ml of serum or urine. Oltipraz was detectable when 2 ng or more of drug was present in 1 ml of serum or urine; the method is highly reproducible when 5 ng/ml or more Oltipraz is present in the biological fluid.