Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Skull base chordoma.

William M Mendenhall1, Charles M Mendenhall, Stephen B Lewis

  • 1Department of Radiation Oncology, University of Florida Health Science Center, PO Box 100385, Gainesville, FL 32610-0385, USA.

Head & Neck
|January 11, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intrinsic and Extrinsic Factors Simultaneously Modulated the Use of Roadways by Golden Eagles During Winter.

Ecology and evolution·2025
Same author

Modelling of a double-scattering proton therapy nozzle using the FLUKA Monte Carlo code and analysis of linear energy transfer in patients treated for prostate cancer.

Journal of applied clinical medical physics·2025
Same author

Predicting the spatial distribution of wintering golden eagles to inform full annual cycle conservation in western North America.

PloS one·2024
Same author

Telehealth in PM&R: Past, present, and future in clinical practice and opportunities for translational research.

PM & R : the journal of injury, function, and rehabilitation·2023
Same author

Demographic partitioning of dynamic energy subsidies revealed with an Ornstein-Uhlenbeck space use model.

Ecological applications : a publication of the Ecological Society of America·2022
Same author

Ecological insights from three decades of animal movement tracking across a changing Arctic.

Science (New York, N.Y.)·2020
Same journal

The Chimeric Thoracodorsal Artery Perforator Flap for Reconstruction After Buccal Cancer Resection: A Retrospective Case Series.

Head & neck·2026
Same journal

Interpreting the Reported Benefits of Virtual Surgical Planning in Mandibular Osteoradionecrosis Reconstruction.

Head & neck·2026
Same journal

Measurement Tools for Radiation-Induced Fibrosis in Head and Neck Cancer: A Systematic Review.

Head & neck·2026
Same journal

Preoperative Predictors of Close or Compromised Surgical Margins in Patients With Oral Squamous Cell Carcinoma.

Head & neck·2026
Same journal

Neoadjuvant Immunochemotherapy Reduces Major Wound Complications in Oral Cancer Surgery.

Head & neck·2026
Same journal

Botulinum Toxin for First Bite Syndrome: A Symptom-Guided "Follow-The-Pain" Injection Strategy.

Head & neck·2026
See all related articles

Optimal treatment for skull base chordomas, rare tumors often in the clivus, involves proton/photon radiotherapy. This approach improves local control rates by allowing higher doses to the tumor while sparing normal tissues.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Neurosurgery

Background:

  • Skull base chordomas are rare tumors typically originating in the clivus.
  • Complete surgical resection is often unfeasible for these tumors.
  • Conventional radiotherapy (RT) for chordomas is limited by severe late complications and low cure rates.

Purpose of the Study:

  • To discuss the optimal treatment strategies and outcomes for patients diagnosed with skull base chordomas.
  • To evaluate the efficacy of different radiotherapy techniques in managing these rare neoplasms.

Main Methods:

  • A comprehensive review of the relevant scientific literature was conducted.
  • Analysis focused on treatment modalities, local control rates, and complications associated with skull base chordomas.

Related Experiment Videos

Main Results:

  • Skull base chordomas are rarely completely resectable, necessitating radiotherapy.
  • Proton/photon radiotherapy offers superior dose distribution compared to conventional photon RT.
  • The 10-year local control rate with proton/photon RT is approximately 40-50%, influenced by tumor dose and homogeneity.

Conclusions:

  • Skull base chordoma is a rare neoplasm with poor outcomes following surgery or conventional RT alone.
  • Proton/photon RT allows for dose escalation to the tumor while minimizing toxicity to surrounding normal tissues.
  • Optimal management may involve proton/photon RT, potentially combined with gross total resection when surgically feasible.