Related Experiment Video
Updated: Aug 20, 2026

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
Published on: August 23, 2024
[New perspectives of treatment of osteoporosis with thiazides]
K Stefiková1, V Spustová, R Dzúrik
1Klinika farmakoterapie, Ustav preventívnej a klinickej mediciny, Bratislava.
Abstract:
Thiazides inhibit calcium and magnesium excretion, the basic substrates of bone mineralization. Clinical investigations pointed already previously to their effectiveness in the prevention and treatment of osteoporosis despite a relatively small effect on the balance. This aroused some distrust and prevented their acceptance among preparations with this indication. They were indicated mainly in patients with hypercalciuria. The results of recent research indicate however their direct inhibition of osteoclasts and in particular stimulation of osteoblasts. This confirms results of clinical investigations which could not be explained previously. It may be foreseen that within a short time thiazides will become an important member in the spectrum of drugs used for the treatment of osteoporosis.
Related Concept Videos
Antihypertensive Drugs: Thiazide-Class Diuretics
Antihypertensive Drugs: Potassium-Sparing Diuretics
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Urinary Tract Calculi III: Medical Management
Oral Hypoglycemic Agents: Biguanides and Glitazones
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...