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An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay
Published on: January 26, 2019
[Congenital rubella syndrome in Costa Rica: importance of active surveillance]
María L Avila-Agüero1, A Morice-Trejos, C Castillo-Solórzano
1Servicio de Infectología, Hospital Nacional de Niños Dr. Carlos Sáenz Herrera, San José, Costa Rica. maluvi@racsa.co.cr
Insights
Congenital rubella syndrome (CRS) was identified in 45 infants under three months old. Increased surveillance and earlier clinical diagnosis are crucial for detecting this preventable infection.
Area of Science:
- Pediatrics
- Infectious Diseases
- Virology
Context:
- Congenital rubella syndrome (CRS) poses a significant threat to infants.
- Early identification and diagnosis are critical for managing CRS.
- Surveillance systems are essential for tracking rubella infections in young children.
Purpose:
- To identify cases of congenital rubella syndrome (CRS) and describe their clinical presentation in infants under three months old.
- To analyze the characteristics of infants diagnosed with CRS between 1996 and 2000.
- To evaluate the diagnostic process for CRS in a national children's hospital.
Summary:
- A retrospective review identified 49 infants under three months with positive rubella IgM serology, of whom 45 were diagnosed with CRS.
- Common presenting symptoms included hepatosplenomegaly, microcephaly, and multiple congenital anomalies.
- The initial clinical diagnosis was often TORCH infection, highlighting diagnostic challenges.
Impact:
- The study underscores the need for enhanced active surveillance of CRS.
- Improved clinical diagnostic criteria and suspicion are vital for early case reporting.
- This research contributes to understanding CRS presentation and informs public health strategies.
Objective:
To identify cases of congenital rubella syndrome (CRS) and their form of presentation in children aged < 3 months in the National Children's Hospital of Costa Rica between 1996 and 2000.
Methods:
Between 1996 and 2000, patients aged 1 day to 3 months with positive IgM serology for rubella, identified by means of the computerized database of the National Children's Hospital Laboratory, were selected. Their corresponding medical records were reviewed and the characteristics of these patients were analyzed.
Results:
Sixty-six children with positive serology were identified, of which 49 had a complete medical record that allowed review. Of these, 29 (60 %) were boys. The mean age at which IgM serology was requested was 33 days. The principal manifestations leading to serology were hepatosplenomegaly, microcephaly and multiple congenital anomalies. The initial diagnosis was TORCH infection. Of the 49 patients, 45 were classified as CRS and four as infection with rubella.
Conclusions:
The present study highlights the need to increase active surveillance of CRS. Greater vigilance in applying the criteria for clinical diagnosis is required to allow an adequate degree of suspicion and early reporting of cases.
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