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Related Experiment Videos

DeltaFosB expression and cataract.

Seiko Aoki1, Yoshio Akagi, Wanchao Ma

  • 1Division of Ophthalmology, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. sa430@aioros.ocn.ne.jp

Experimental Eye Research
|January 12, 2005
PubMed
Summary
This summary is machine-generated.

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DeltaFosB expression in the lens, but not the retina, causes posterior subcapsular cataract. This study clarifies the specific tissue contribution of DeltaFosB to cataract development.

Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Genetics

Background:

  • DeltaFosB, a truncated FosB transcription factor, is implicated in cataract formation.
  • Previous studies showed transgenic mice expressing DeltaFosB in both retina and lens developed posterior subcapsular cataracts.

Purpose of the Study:

  • To determine if DeltaFosB expression in the lens or retina alone is sufficient to cause cataract.
  • To clarify the specific contribution of each tissue to DeltaFosB-induced cataract development.

Main Methods:

  • Generated transgenic mice with targeted DeltaFosB expression in either the lens (R2betaB1DeltaFosB) or retina (RhoDeltaFosB).
  • Monitored DeltaFosB expression via Western blotting.
  • Assessed cataract development using slit-lamp examination.

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Main Results:

  • Mice with retinal DeltaFosB expression (RhoDeltaFosB) showed no signs of lens opacity.
  • One line of mice with lens-specific DeltaFosB expression (R2betaB1DeltaFosB) developed posterior subcapsular cataract.
  • Retinal expression of DeltaFosB alone did not induce cataract.

Conclusions:

  • DeltaFosB expression in the retina is insufficient to cause cataract.
  • Exclusive DeltaFosB expression in the lens is sufficient to induce posterior subcapsular cataract.
  • Lens-specific expression of DeltaFosB is the critical factor in this model of cataractogenesis.