Related Experiment Video
Updated: Aug 20, 2026

High-throughput Functional Screening using a Homemade Dual-glow Luciferase Assay
Published on: June 1, 2014
Failure to find alpha-synuclein gene dosage changes in 190 patients with familial Parkinson disease
Suzana Gispert1, Claudia Trenkwalder, Luisa Mota-Vieira
1Institute for Experimental Neurobiology, University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany.
Background:
Recently, a triplication of the alpha-synuclein locus was found associated with autosomal dominant Parkinson disease in a large family.
Objective:
To determine whether a triplication or some other dosage alteration in the alpha-synuclein gene is present in one or more patients with familial PD in a large multinational collective.
Design:
Retrospective recruitment of the largest families who were willing to cooperate with the study.
Setting:
Centers with specialization in movement disorders genetics.
Patients:
One hundred ninety unrelated patients with familial PD from Germany, Portugal, and Yugoslavia.
Main Outcome Measures:
Alpha-synuclein gene dosage values measured with real-time polymerase chain reaction.
Results:
None of the samples showed alpha-synuclein triplication, duplication, or deletion.
Conclusion:
Alterations in alpha-synuclein gene dosage are rare in familial PD.
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