Related Experiment Video
Updated: Jul 12, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
Prevalence and correlates of depression among veterans with multiple sclerosis
R M Williams1, A P Turner, M Hatzakis
1Department of Veterans Administration Puget Sound Health Care System, Seattle Division, Rehabilitation Care Services, S-117, 1660 S. Columbian Way, Seattle, WA 98108, USA. Rhonda.Williams1@med.va.gov
Objectives:
To establish the prevalence of major depressive episode (MDE) in a large sample of veterans with multiple sclerosis (MS); to identify demographic characteristics, aspects of disease presentation, and perceptions of disability associated with greater concurrent risk for MDE; and to examine the relationship between MDE, service utilization, and activity participation.
Methods:
Veterans with MS (n = 1,032) were identified via computer database and surveyed by mail; 451 (43.7%) responded.
Results:
Twenty-two percent of the sample met criteria for current MDE. Low income, unemployment, presence of falls, younger age, absence of a marital partner, and high levels of perceived disability due to bowel functioning were independently associated with MDE. Disease subtype, disease duration, use of disease modifying therapies, and perceived disability due to mobility or bladder problems were unrelated to MDE. Current MDE was in turn associated with increased primary care visits and increased impact of disease upon activity participation. Similar correlates were associated with minor depressive episode.
Conclusions:
Unlike the general population, rates of depression in this predominantly male sample were similar to those found in predominantly female samples of persons with multiple sclerosis. Specific aspects of disability were differentially associated with depression, and depression was independently associated with increased service utilization and increased participation limitations.
Insights
Depression affects 22% of veterans with multiple sclerosis (MS). Factors like low income and perceived disability increase risk, while depression impacts healthcare use and activity participation.
Area of Science:
- Neurology
- Psychiatry
- Public Health
Background:
- Multiple sclerosis (MS) is a chronic neurological disease.
- Depression is a common comorbidity in MS, affecting quality of life.
- Understanding depression prevalence and risk factors in veterans with MS is crucial for targeted interventions.
Purpose of the Study:
- To determine the prevalence of major depressive episode (MDE) in veterans with MS.
- To identify demographic, disease-related, and disability-related factors associated with MDE.
- To examine the link between MDE, healthcare service utilization, and participation in activities.
Main Methods:
- A survey was mailed to 1,032 veterans with MS identified through a computer database.
- A response rate of 43.7% (451 veterans) was achieved.
- Statistical analyses identified factors associated with MDE and its impact.
Main Results:
- Twenty-two percent of the surveyed veterans met criteria for current MDE.
- Independent predictors of MDE included low income, unemployment, falls, younger age, lack of a partner, and perceived disability from bowel issues.
- MDE was associated with increased primary care visits and limitations in activity participation.
Conclusions:
- Depression rates in this male-predominant veteran MS sample mirrored those in female-predominant MS populations.
- Specific disability perceptions, particularly bowel functioning, were linked to depression.
- Depression in veterans with MS is associated with higher healthcare utilization and reduced participation in daily activities.
Related Concept Videos
Long-term Depression
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Depression: Overview
Depressive Disorders: MDD and Dysthymia
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Multiple Sclerosis l: Introduction

