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Related Experiment Videos

[Peripheral nervous system in limited systemic sclerosis].

A Del Rosso1, L Ibba Manneschi, A Tani

  • 1Dipartimento di Medicina Interna, Divisione di Reumatologia, Università di Firenze, 50139 Firenze, Italy. angedelr@tin.it

Reumatismo
|January 12, 2005
PubMed
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Peripheral nerve system (PNS) fibers in systemic sclerosis (SSc) show minimal damage in early stages but develop slight ultrastructural alterations in advanced limited SSc (lSSc) skin, indicating disease progression impacts nerve fibers.

Area of Science:

  • Dermatology
  • Neurology
  • Pathology

Background:

  • Peripheral nerve system (PNS) involvement is recognized in the early stages of Systemic Sclerosis (SSc).
  • Understanding the ultrastructural changes in skin PNS fibers is crucial for SSc pathogenesis.

Purpose of the Study:

  • To conduct an ultrastructural examination of skin PNS fibers in patients with Systemic Sclerosis (SSc).
  • To investigate the relationship between disease duration and PNS fiber integrity in limited SSc (lSSc).

Main Methods:

  • Skin biopsies were obtained from 8 lSSc patients and 3 controls.
  • Transmission electron microscopy (TEM) was employed for ultrastructural analysis of semithin and ultrathin sections.

Main Results:

Related Experiment Videos

  • Early lSSc showed inflammation and microvessel damage, with unaffected PNS fibers.
  • Advanced lSSc exhibited prevailing fibrosis and slight ultrastructural alterations in papillary dermal PNS fibers.

    • Conclusions:

    • PNS fiber lesions in lSSc vary in severity based on disease duration.
    • More severe PNS fiber alterations are observed in the advanced stages of lSSc compared to the early stages.