Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malleomyringoplasty using a silicone prosthesis.

A Schiller1, P J Wormald

  • 1Department of Otolaryngology, Groote Schuur Hospital, Observatory, Cape Town, South Africa.

The Journal of Laryngology and Otology
|March 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Staphylococcus aureus and Staphylococcus lugdunensis Act in Concert to Disrupt the Nasal Epithelial Barrier.

Clinical and translational allergy·2026
Same author

Biofilm Exoproteins From Staphylococcus Species Impede Re-Epithelialization of Nasal Epithelial Cells During Wound Healing and Cease Ciliary Beat Frequency.

International forum of allergy & rhinology·2026
Same author

Motion analysis for objective evaluation of psychomotor skills in Endoscopic Sinus Surgery.

Rhinology·2024
Same author

Can high-fidelity 3D models be a good alternative for cadaveric materials in skill assessment for endoscopic sinus surgery? A comparison study in assessment for surgical performance in 3D models and cadavers.

Frontiers in medicine·2024
Same author

Characterising the allergic fungal rhinosinusitis microenvironment using full-length 16S rRNA gene amplicon sequencing and fungal ITS sequencing.

Allergy·2024
Same author

Deferiprone and Gallium-Protoporphyrin Chitogel as an antimicrobial treatment: Preclinical studies demonstrating antimicrobial activity for S. aureus infected cutaneous wounds.

International journal of biological macromolecules·2024

This study explored a new silicone prosthesis for total ear reconstruction in rats. The prosthesis showed high success rates, indicating potential for human trials in treating hearing loss.

Area of Science:

  • Otolaryngology
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Middle ear reconstruction faces challenges like infection and prosthesis failure.
  • Current methods for tympanic membrane and ossicular chain repair have limitations.

Purpose of the Study:

  • To evaluate a novel silicone prosthesis for total replacement of the tympanic membrane and ossicular chain in an animal model.
  • To assess the biocompatibility and long-term stability of the silicone prosthesis.

Main Methods:

  • A silicone prosthesis, encased in fascia, was implanted in thirty rats to replace the tympanic membrane and ossicular chain.
  • The prostheses were evaluated after four months for integrity, infection, and extrusion.

Main Results:

Related Experiment Videos

  • The silicone prosthesis remained intact in 29 out of 30 rats after four months.
  • No evidence of infection or extrusion was observed in the successful cases.

Conclusions:

  • The fascia-wrapped silicone prosthesis demonstrates promising biocompatibility and stability for total ear reconstruction.
  • These findings support the potential clinical application of this prosthesis in human patients requiring middle ear repair.