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Updated: Aug 12, 2026

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
Published on: April 29, 2011
Doppler estimation of zero flow pressure during changes in downstream pressure in a bench model of a circulation
L Athanassiou1, S M Hancock, R P Mahajan
1IASO General Hospital, 264 Mesogion Avenue, Holargos, Athens 155 62, Greece.
Abstract:
Zero flow pressure is the arterial pressure at which blood flow ceases in the cerebral circulation and may represent the effective downstream pressure of this system. We used a bench model of pulsatile fluid flow to determine whether simulated changes in downstream pressure may be detected by estimation of zero flow pressure. A Doppler probe was used to record flow velocity and a pressure transducer was used to measure driving pressure. Eight different configurations of the circuit were produced, and at each configuration the external pressure around a collapsible segment of the circuit was changed in order to simulate intracranial pressure. Perfusion pressure and zero flow pressure were estimated for each configuration and each level of external pressure. The sensitivity of the model in predicting the change in external pressure from the change in zero flow pressure was 94%. This indicates that estimation of zero flow pressure by this method is a sensitive way of monitoring trends in changes in downstream pressure.
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