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Related Experiment Videos

Furazolidone-induced pulmonary hypersensitivity.

Todd J Kowalski1, Michael J Henry, Jonathan A Zlabek

  • 1Division of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA. Kowalski.Todd@Mayo.edu

The Annals of Pharmacotherapy
|January 13, 2005
PubMed
Summary

Furazolidone, a medication for enteritis, can cause pulmonary hypersensitivity. This case highlights the potential for serious lung reactions, similar to nitrofurantoin, emphasizing the need for clinical awareness.

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Area of Science:

  • Pulmonology
  • Pharmacology
  • Internal Medicine

Background:

  • Furazolidone is an antimicrobial agent used for infectious enteropathies.
  • Pulmonary hypersensitivity reactions are a known adverse effect of certain medications, notably nitrofurantoin.
  • The chemical similarity between furazolidone and nitrofurantoin suggests a potential for similar adverse reactions.

Observation:

  • A 43-year-old female presented with acute onset of fever, dyspnea, hypoxia, and bibasilar interstitial infiltrates on chest X-ray.
  • The patient had recently completed a 10-day course of furazolidone for enteritis.
  • Investigations revealed significant peripheral eosinophilia (21%).

Findings:

  • The patient's symptoms rapidly improved upon discontinuation of furazolidone and initiation of corticosteroid therapy.

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  • The Naranjo probability scale indicated a probable adverse drug reaction to furazolidone.
  • A literature review identified two prior cases suggesting furazolidone-induced pulmonary hypersensitivity.

    • Implications:

    • Furazolidone may be an underrecognized cause of drug-induced pulmonary hypersensitivity.
    • Clinicians should consider furazolidone as a potential etiology in patients presenting with unexplained pulmonary symptoms, especially after recent exposure.
    • Awareness of this potential adverse effect is crucial for timely diagnosis and management of furazolidone-induced lung injury.