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Related Experiment Videos

Facility design considerations for select agent animal research.

Dan Frasier1, Jeff Talka

  • 1Commissioning Services, Cornerstone Commissioning, Inc., Boxford, Massachusetts, USA.

ILAR Journal
|January 13, 2005
PubMed
Summary

Following 9/11, US investment in infectious disease research facilities, including biosafety level (BSL)-3 and BSL-4, surged by over 900%. This necessitated collaboration for designing and constructing specialized biocontainment labs.

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Area of Science:

  • Biosecurity and Infectious Disease Research
  • Laboratory Design and Construction
  • Public Health Preparedness

Background:

  • The September 11, 2001 attacks significantly increased US focus and funding for infectious disease research.
  • Federal grants for biosafety level (BSL)-3, BSL-3 Agricultural (Ag), and BSL-4 research facilities saw a dramatic increase of over 900% from 1999-2001 to 2002-2004.
  • This rapid expansion required interdisciplinary collaboration among government, academia, industry, and construction professionals.

Purpose of the Study:

  • To provide an overview of guidelines and standards for designing and constructing biocontainment research facilities, particularly those using animals.
  • To discuss essential design considerations for these specialized research environments.
  • To highlight specific requirements for BSL-3Ag agricultural research and prepare users for state-of-the-art facilities.

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Main Methods:

  • Review of existing guidelines and standards relevant to biocontainment facility design.
  • Analysis of design considerations for animal research within biocontainment settings.
  • Identification of unique requirements for BSL-3Ag facilities.

Main Results:

  • Established guidelines and standards are crucial for the safe design and construction of biocontainment facilities.
  • Specific design considerations are necessary to meet the demanding needs of infectious disease research, including animal use.
  • BSL-3Ag research entails specialized requirements distinct from other biosafety levels.

Conclusions:

  • The increased investment in infectious disease research necessitates adherence to stringent guidelines for facility design and construction.
  • Effective biocontainment facilities require careful planning, collaboration, and attention to unique research needs, including those involving animals and agricultural pathogens.
  • Understanding these design principles and requirements is vital for the successful operation of advanced infectious disease research laboratories.