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Implications of carotid arteriomegaly in patients with aortic aneurysm

Toshihiko Iwamoto1, Akihiro Kimura, Toshinori Nakai

  • 1The Brain & Blood Vessel Laboratory, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023 Japan. i-wam@ma.kcom.ne.jp

Journal of Atherosclerosis and Thrombosis
|January 13, 2005
PubMed

Insights

Arteriomegaly, a diffuse arterial dilation, is frequently associated with arteriosclerotic aortic aneurysm (AA). This study found that nearly one-fourth of AA patients exhibit this generalized arterial abnormality.

Area of Science:

  • Vascular Biology
  • Cardiovascular Medicine
  • Medical Imaging

Background:

  • The complex pathophysiology of aortic aneurysms is not fully understood.
  • The association between arteriomegaly (diffuse arterial dilatation) and aortic aneurysms requires clarification.

Purpose of the Study:

  • To investigate the frequency of carotid arteriomegaly in patients with arteriosclerotic aortic aneurysm (AA).
  • To compare the prevalence of carotid arteriomegaly across different cardiovascular conditions.

Main Methods:

  • Carotid ultrasonography was performed on 1,108 Japanese men aged 50+.
  • Carotid diameter was measured, defining arteriomegaly as the 95th percentile or higher compared to normotensive controls.
  • Data were compared between AA patients and those with peripheral arterial disease, aortic dissection, hypertension, and normotensive controls.

Main Results:

  • The incidence of carotid arteriomegaly was significantly higher in the AA group (25.9%) compared to all other groups (p < 0.01).
  • This association remained significant after adjusting for body height and blood pressure.
  • Hypertension and smoking were more prevalent in the arteriomegaly subgroup.

Conclusions:

  • Arteriomegaly is a generalized systemic abnormality in the arterial wall, frequently observed in patients with aortic aneurysms.
  • Approximately one-fourth of patients with arteriosclerotic aortic aneurysms exhibit associated arteriomegaly.

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