Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple sclerosis. Observations and reflections--a personal memoir.

C M Poser1

  • 1Department of Neurology, Harvard Medical School, Boston, MA.

Journal of the Neurological Sciences
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exercise and Alzheimer's Disease, Parkinson's Disease, and Multiple Sclerosis.

The Physician and sportsmedicine·2016
Same author

Disseminated encephalomyelitis and multiple sclerosis: two different diseases - a critical review.

Acta neurologica Scandinavica·2007
Same author

The diagnosis and management of multiple sclerosis.

Acta neurologica Scandinavica·2005
Same author

Multiple sclerosis trait: the premorbid stage of multiple sclerosis. A hypothesis.

Acta neurologica Scandinavica·2004
Same author

Optic neuromyelitis syndrome in Brazilian patients.

Journal of neurology, neurosurgery, and psychiatry·2002
Same author

Problems with diagnostic criteria for multiple sclerosis.

Lancet (London, England)·2001

Genetic susceptibility plays a key role in multiple sclerosis (MS) pathogenesis, challenging previous environmental theories. Advances in epidemiology and neuroimaging offer new insights into MS development and risk factors.

Area of Science:

  • Neuroimmunology
  • Epidemiology
  • Genetics

Background:

  • Recent advances in epidemiology and neuroimaging have improved understanding of multiple sclerosis (MS) pathogenesis.
  • Traditional views on MS prevalence, latitude, and epidemics require revision.
  • Genetic factors are now recognized as more significant than environmental factors in MS development, though environmental influences remain relevant.

Purpose of the Study:

  • To revise epidemiological conclusions regarding MS prevalence and its relationship with latitude.
  • To emphasize the significant role of genetic susceptibility in MS genesis.
  • To explore the potential role of early-life events, such as viral infections or vaccinations, in initiating the disease process.

Main Methods:

  • Review and re-evaluation of epidemiological data.

Related Experiment Videos

  • Analysis of neuroimaging findings related to blood-brain barrier integrity.
  • Integration of genetic and environmental factor research in MS.

    • Main Results:

    • The direct relationship between MS prevalence and latitude is questioned.
    • Genetic susceptibility, particularly in individuals of northern European descent, is a critical factor.
    • An initial "MS trait," possibly triggered by viral illness or vaccination before puberty, alters immune function and blood-brain barrier permeability.

    Conclusions:

    • MS pathogenesis involves a complex interplay of genetic predisposition and environmental triggers.
    • A compromised blood-brain barrier is a crucial step in MS development, confirmed by neuroimaging.
    • The initial lesion may not always lead to clinical disease, and the precise mechanisms of myelin damage remain under investigation.