Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiological study of the spinothalamic tract conduction in multiple sclerosis.

R Kakigi1, Y Kuroda, R Neshige

  • 1Department of Internal Medicine, Saga Medical School, Japan.

Journal of the Neurological Sciences
|February 1, 1992
PubMed
Summary

This study reveals that pain-related somatosensory evoked potentials (pain SEPs) can detect spinothalamic tract dysfunction in multiple sclerosis (MS) patients, correlating with sensory loss.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effectiveness of adding Braun anastomosis to standard Child reconstruction to reduce delayed gastric emptying after pancreatoduodenectomy (REMBRANDT): study protocol for a multicentre randomised-controlled trial.

Trials·2025
Same author

Immunophenotypic shift from CD4(+) to CD8(+) in mycosis fungoides.

The British journal of dermatology·2016
Same author

A randomized phase III trial of postoperative adjuvant therapy for completely resected stage IA-IIIA lung cancer using an anti‑angiogenetic agent: irsogladine maleate.

Minerva chirurgica·2013
Same author

Carcinoembryonic antigen-related cell adhesion molecules as surrogate markers for EGFR inhibitor sensitivity in human lung adenocarcinoma.

British journal of cancer·2012
Same author

[Emergency anterior approach for decortication with right pneumonectomy in a patient with chronic expanding hematoma].

Kyobu geka. The Japanese journal of thoracic surgery·2011
Same author

[Management of surgical approach for intractable secondary spontaneous pneumothorax].

Kyobu geka. The Japanese journal of thoracic surgery·2011

Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Electrophysiology

Background:

  • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • The spinothalamic tract is crucial for pain and temperature sensation.
  • Assessing the physiological function of spinal tracts in MS is vital for understanding disease progression and sensory deficits.

Purpose of the Study:

  • To investigate the physiological function of the spinothalamic tract in multiple sclerosis (MS) patients.
  • To evaluate the utility of pain-related somatosensory evoked potentials (pain SEPs) in assessing MS-related neurological impairment.
  • To correlate electrophysiological findings with clinical sensory deficits.

Main Methods:

  • Utilized CO2 laser stimulation to elicit pain SEPs in 12 MS patients.

Related Experiment Videos

  • Recorded hand- and foot-stimulated pain SEPs.
  • Compared pain SEP results with conventional electrically-stimulated SEPs.
  • Correlated electrophysiological data with clinical assessments of pain, temperature, and vibration sensation.

    • Main Results:

    • Pain SEPs were significantly delayed or absent in 3/12 (hand) and 7/12 (foot) MS patients.
    • Findings were consistent with clinical impairment of pain-temperature sensation.
    • Electrically-stimulated SEPs correlated with impairment of vibration sensation.

    Conclusions:

    • Pain SEPs are a valuable tool for assessing spinothalamic tract function in MS.
    • Combined assessment of pain and electric SEPs provides comprehensive evaluation of ascending spinal tract physiology in MS.
    • This approach aids in understanding the relationship between electrophysiological changes and clinical symptoms in MS.