Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development and malformations of the human pyramidal tract.

H J ten Donkelaar1, M Lammens, P Wesseling

  • 1Department of Neurology, University Medical Centre Nijmegen, P. O. Box 9101, 6500 HB Nijmegen, The Netherlands. H.tenDonkelaar@neuro.umcn.nl

Journal of Neurology
|January 13, 2005
PubMed
Summary

The corticospinal tract, crucial for motor control, undergoes complex development with potential for malformations. Understanding its developmental disorders is key to addressing neurological conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing owner reported and genetic breed identification reveals high concordance in a large cohort from the Dog Aging Project.

Scientific reports·2025
Same author

Induced neural phase precession through exogeneous electric fields.

bioRxiv : the preprint server for biology·2023
Same author

Distress and post-traumatic stress in parents of patients with congenital gastrointestinal malformations: a cross-sectional cohort study.

Orphanet journal of rare diseases·2022
Same author

Optimisation of Radiation Therapy in Bladder Preservation Therapy for Patients With Clinical Stage T2N0M0 Bladder Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2022
Same author

Cost utility analysis of pharmacist counseling care for breast cancer chemotherapy outpatients.

Die Pharmazie·2019
Same author

Combating 'fake news' and social stigma after the Fukushima Daiichi Nuclear Power Plant incident-the importance of accurate longitudinal clinical data.

QJM : monthly journal of the Association of Physicians·2019

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Neuroanatomy

Background:

  • The corticospinal tract is the primary motor pathway, developing over an extended period.
  • Rodent and primate corticospinal tract development show species-specific timing, with primates developing largely prenatally.
  • Gene involvement in pyramidal tract development is increasingly recognized in mice.

Purpose of the Study:

  • To review the developmental process of the corticospinal tract.
  • To explore malformations associated with this motor pathway.
  • To discuss the spectrum of developmental disorders affecting the pyramidal tract.

Main Methods:

  • Review of neuropathological and clinical literature.
  • Analysis of autopsy cases.

Related Experiment Videos

  • Synthesis of data on corticospinal tract development and malformations.

    • Main Results:

    • Corticospinal tract development involves extensive initial projections that are selectively eliminated.
    • Direct corticomotoneuronal projections are late-developing components.
    • Variations and malformations, including uncrossed pyramidal tracts, occur during development.
    • Pyramidal tract malformations are linked to cortical patterning, neurogenesis, migration, white matter injury, and axon guidance defects.

    Conclusions:

    • The human pyramidal tract likely develops similarly to other mammals, with a prolonged maturation process.
    • A wide range of developmental disorders can involve pyramidal tract malformations.
    • Abnormal axon guidance and molecular mechanisms underlie some of these malformations.