Related Experiment Video
Updated: Aug 20, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
Published on: January 9, 2026
Acute pancreatitis and its association with diabetes mellitus in children
S D Shenoy1, D Cody, A B Rickett
1Department of Paediatrics, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK.
Insights
Acute pancreatitis is more common in children than previously thought, though permanent diabetes mellitus is rare. Early pancreatic imaging is advised for children with severe abdominal pain.
Area of Science:
- Pediatric Gastroenterology
- Endocrinology
Background:
- Acute pancreatitis is increasingly recognized in pediatric populations.
- Understanding its association with metabolic disturbances is crucial.
Observation:
- Hyperglycemia and glycosuria are common during acute pancreatitis episodes in children.
- Permanent diabetes mellitus is an infrequent outcome.
Findings:
- Acute pancreatitis and diabetic ketoacidosis share a bidirectional causal relationship.
- Severe, prolonged abdominal pain in children warrants pancreatic evaluation.
Implications:
- Highlights the need for heightened awareness of pediatric pancreatitis.
- Suggests early diagnostic imaging for severe abdominal pain in children.
- Emphasizes the link between pancreatitis and glucose dysregulation.
Abstract:
Acute pancreatitis is more common in childhood than has been appreciated previously. During acute attacks of pancreatitis, hyperglycaemia and glycosuria are not uncommon but permanent diabetes mellitus is rare. Acute pancreatitis can also be associated with diabetic ketoacidosis and the association between these two is of a two-way cause and effect relationship. Early imaging of the pancreas is recommended in children with severe prolonged abdominal pain.
Related Concept Videos
Acute Pancreatitis II: Clinical Manifestations and Management
Acute Pancreatitis I: Introduction
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Chronic Pancreatitis II: Pathophysiology
Chronic Pancreatitis I: Introduction

